Abstract Background The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells.The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands, thereby facilitating the cancer ce
At the origin of the International Law Department were such eminent scientists, diplomats and teachers as V.N.Durdenevsky, S.B.Krylov china glaze beaches and toes and F.I.Kozhevnikov.International law studies in USSR and Russia during the second half of the XX century was largely shaped by the lawyers of MGIMO.They had a large influence on the educ
The certification of the CMS experiment data as usable for physics analysis is a crucial task to ensure the m7 mega truck quality of all physics results published by the collaboration.Currently, the certification conducted by human experts is labor intensive and based on the scrutiny of distributions integrated on several hours of data taking.This
Landscape quality has become a fundamental issue in the development of renewable energy (henceforth abbreviated RE) projects.Rapid technological advances in RE production and distribution, coupled with changing policy frameworks, bring specific challenges during planning in order to avoid degradation of landscape quality.The current work opi all ab